Копылов Алексей Михайлович
ведущий научный сотрудник

Избранные статьи

1. Golovin Andrey, Dzarieva Fatima, Rubetskaya Ksenia, Shamadykova Dzhirgala, Usachev Dmitry, Pavlova Galina, Kopylov Alexey (2025) In Silico Born Designed Anti-EGFR Aptamer Gol1 Has Anti-Proliferative Potential for Patient Glioblastoma Cells. International Journal of Molecular Sciences, >>


2. Ivko V., Antipova O., Ivanov B., Tashlitsky V., Dzarieva F., Samoylenkova N., Usachev D., Pavlova G., Kopylov A. (2025) Real-Time Kinetics of Internalization of Anti-EGFR DNA Aptamers and Aptamer Constructs into Cells Derived from Glioblastoma Patients as Indicated by Doxorubicin. International Journal of Molecular Sciences, >>


3. Kolesnikova Varvara, Revishchin Alexander, Alekseeva Anna, Usachev Dmitry, Kopylov Alexey, Pavlova Galina (2025) The GQIcombi сocktail attenuates glioblastoma growth in vivo using the rat glioblastoma 101/8 model. Biochemical and Biophysical Research Communications, >>


4. Postnov Andrey A., Pronin Igor N., Vikhrova Nina B., Kalaeva Diana B., Pyzhik Elena V., Lipengolts Alexey A., Revishchin Alexander V., Dzarieva Fatima M., Sliman Yahya A., Golovin Andrey V., Korshun Vladimir A., Brylev Vladimir A., Skribitsky Vsevolod A., (2025) A PET-CT study of the uptake of labeled aptamers [18F]FB-Gol1 and [18F]FB-GR20 in rat 101.8 glioblastoma model. Frontiers in oncology, >>


5. Pavlova Svetlana, Rubetskaya Ksenia, Fab Lika, Savchenko Ekaterina, Samoylenkova Nadezhda, Revishchin Alexander, Ryabova Anastasia, Antipina Natalia, Galkin Mikhail, Golanov Andrey, Usachev Dmitry, Kopylov Alexey, Pavlova Galina (2025) The Aptamer bi-(AID-1-T) Synergizes with Radiation to Inhibit Proliferation of Human Glioma Cells. Pharmaceutics, >>


6. Brylev Vladimir A., Ryabukhina Ekaterina V., Nazarova Ekaterina V., Samoylenkova Nadezhda S., Gulyak Evgeny L., Sapozhnikova Ksenia A., Dzarieva Fatima M., Ustinov Alexey V., Pronin Igor N., Usachev Dmitry Y., Kopylov Alexey M., Golovin Andrey V., Pavlova (2024) Towards Aptamer-Targeted Drug Delivery to Brain Tumors: The Synthesis of Ramified Conjugates of an EGFR-Specific Aptamer with MMAE on a Cathepsin B-Cleavable Linker. Pharmaceutics, >>


7. Moiseenko Valeria L., Antipova Olga M., Rybina Aleksandra A., Mukhametova Liliya I., Eremin Sergei A., Pavlova Galina V., Kopylov Alexey M. (2024) Post-Selection Design of Aptamers: Comparative Study of Affinity of the DNA Aptamers to Recombinant Extracellular Domain of Human Epidermal Growth Factor Receptors. Biochemistry (Moscow), >>


8. Dzarieva F.M., Shamadykova D.V., Sluchanko O.V., Pavlova S.A., Fab L.V., Ryabova A.V., Panteleev D.Yu, Kopylov A.M., Usachev D.Yu, Golovin A.V., Pavlova G.V. (2024) Specificity of Aptamers U2 and Gol1 to EGFR-Positive Human Glioblastoma Cells in Vitro. Neuroscience and Behavioral Physiology, >>


9. Pavlova Svetlana, Fab Lika, Dzarieva Fatima, Ryabova Anastasia, Revishchin Alexander, Panteleev Dmitriy, Antipova Olga, Usachev Dmitry, Kopylov Alexey, Pavlova Galina (2024) Unite and Conquer: Association of Two G-Quadruplex Aptamers Provides Antiproliferative and Antimigration Activity for Cells from High-Grade Glioma Patients. Pharmaceuticals, >>


10. Antipova Olga, Moiseenko Valeria, Dzarieva Fatima, Savchenko Ekaterina, Pronin Igor, Pavlova Galina, Kopylov Alexey (2024) Varieties of interactions of anti-CD133 aptamers with cell cultures from patient glioblastoma. SLAS DISCOVERY, >>


11. Ivanov B.M., Antipova O.M., Sliman Ya A., Samoylenkova N.S., Pronin I.N., Pavlova G.V., Kopylov A.M. (2024) Use of Anti-EGFR Aptamer Construct GR20hh for Controlled Delivery of Doxorubicin into Patient-Derived Glioblastoma Cells. Neuroscience and Behavioral Physiology, >>


12. Иванов Б.М., Антипова О.М., Слиман Я.А., Самойленкова Н.С., Пронин И.Н., Павлова Г.В., Копылов А.М. (2024) ИСПОЛЬЗОВАНИЕ АНТИ-EGFR АПТАМЕРНОЙ КОНСТРУКЦИИ GR20hh ДЛЯ РЕГУЛИРУЕМОЙ ДОСТАВКИ ДОКСОРУБИЦИНА В КЛЕТКИ ГЛИОБЛАСТОМЫ ПАЦИЕНТА. Журнал высшей нервной деятельности им. И. П. Павлова, >>


13. Pavlova S., Fab L., Savchenko E., Ryabova A., Ryzhova M., Revishchin A., Pronin I., Usachev D., Kopylov A., Pavlova G. (2024) The Bi-(AID-1-T) G-Quadruplex Has a Janus Effect on Primary and Recurrent Gliomas: Anti-Proliferation and Pro-Migration. Pharmaceuticals, >>


14. Sliman Ya A., Samoylenkova N.S., Antipova O.M., Brylev V.A., Veryutin D.A., Sapozhnikova K.A., Alekseeva A.I., Pronin I.N., Kopylov A.M., Pavlova G.V. (2024) Covalently conjugated DNA aptamer with doxorubicin as in vitro model for effective targeted drug delivery to human glioblastoma tumor cells. Вопросы нейрохирургии имени Н.Н.Бурденко, >>


15. Moiseenko V.L., Antipova O.M., Pavlova S.A., Pronin I.N., Pavlova G.V., Kopylov A.M. (2024) Возможна ли детекция поверхностного антигена CD133 на перевиваемых культурах клеток глиобластомы пациентов с помощью флуоресцентных аптамеров?. Вопросы нейрохирургии имени Н.Н.Бурденко, >>


16. Моисеенко В.Л., Антипова О.М., Рыбина А.А., Мухаметова Л.И., Ерёмин С.А., Павлова Г.В., Копылов А.М. (2024) Постселекционное конструирование аптамеров: сравнительное исследование аффинности ДНК-аптамеров к рекомбинантному внеклеточному домену рецептора эпидермального фактора роста человека. Биохимия, >>


17. Il’in Viktor Al, Pyzhik Elena V., Balakhonov Anton B., Kiryushin Maksim A., Shcherbatova Evgeniya V., Kuznetsov Andrey A., Kostin Pavel A., Golovin Andrey V., Korshun Vladimir A., Brylev Vladimir A., Sapozhnikova Kseniya A., Kopylov Alexey M., Pavlova Gal (2023) Radiochemical Synthesis of 4-[18F]FluorobenzylAzide and Its Conjugation with EGFR-Specific Aptamers. Molecules, >>


18. Копылов А.М., Антипова О.А., Павлова Г.В. (2022) Молекулярные маркеры нейроонкогенеза при глиобластоме головного мозга. Вопросы нейрохирургии имени Н.Н.Бурденко, >>


19. Pavlova Galina, Kolesnikova Varvara, Samoylenkova Nadezhda, Drozd Sergey, Revishchin Alexander, Shamadykova Dzhirgala, Usachev Dmitry Y., Kopylov Alexey (2022) A Combined Effect of G-Quadruplex and Neuro-Inducers as an Alternative Approach to Human Glioblastoma Therapy. Frontiers in oncology, >>