Boris A. Feniouk
Deputy Director for Research
Deputy Director for Research.
Research interests: molecular mechanism and physiological role of regulation of proton-dependent ATP synthase activity.
The proton translocating FOF1-ATP synthase (F-type ATPase, F-ATPase or FOF1), found in mitochondria, chloroplasts and most eubacteria, is one of the key enzymes in bioenergetics. The enzyme performs ATP synthesis / hydrolysis coupled with proton transport across the membrane. ATPase activity of the enzyme is suppressed in the absence of proton-motive force by several regulatory mechanisms. The most conservative of these mechanisms found in all studied ATP synthases is the allosteric inhibition of ATP activity by the MgADP complex (ADP inhibition).
Research interests: molecular mechanism and physiological role of regulation of proton-dependent ATP synthase activity.
The proton translocating FOF1-ATP synthase (F-type ATPase, F-ATPase or FOF1), found in mitochondria, chloroplasts and most eubacteria, is one of the key enzymes in bioenergetics. The enzyme performs ATP synthesis / hydrolysis coupled with proton transport across the membrane. ATPase activity of the enzyme is suppressed in the absence of proton-motive force by several regulatory mechanisms. The most conservative of these mechanisms found in all studied ATP synthases is the allosteric inhibition of ATP activity by the MgADP complex (ADP inhibition).
Articles
- Litvin A.V., Lapashina A.S., Ermidis A.P., Gelfand M.S., Feniouk B.A. (2025) ProAD – A database of rotary ion-translocating ATPases in prokaryotic genomes. Frontiers in Molecular Biosciences, >>
- Bruman Sofya M., Zubareva Valeria M., Shugaeva Tatiana E., Lapashina Anna S., Feniouk Boris A. (2025) Activation of Bacterial F-ATPase by LDAO: Deciphering the Molecular Mechanism. Biochemistry (Moscow), >>
- Бруман С.М., Зубарева В.М., Шугаева Т.Е., Лапашина А.С., Фенюк Б.А. (2025) ИССЛЕДОВАНИЕ МОЛЕКУЛЯРНОГО МЕХАНИЗМА УСИЛЕНИЯ АТФазной АКТИВНОСТИ БАКТЕРИАЛЬНОЙ АТФ-СИНТАЗЫ ДЕТЕРГЕНТОМ LDAO. Biochemistry (Moscow), >>
- Páli Tibor, Feniouk Boris, Wilkens Stephan (2024) Editorial: Functions, working mechanisms, and regulation of rotary ATPases and Ductin proteins. Frontiers in Molecular Biosciences, >>
- Бруман С.М., Литвин А.В., Лапашина А.С., Фенюк Б.А. (2024) Введение “натриевой подписи” в субъединицы a и с протонной F-АТФазы Bacillus sp. PS3 не приводит к появлению натриевой специфичности. Микробиология,
- Lapashina Anna S., Kashko Nataliia D., Zubareva Valeria M., Galkina Kseniia V., Markova Olga V., Knorre Dmitry A., Feniouk Boris A. (2022) Attenuated ADP-inhibition of FOF1 ATPase mitigates manifestations of mitochondrial dysfunction in yeast. Biochimica et Biophysica Acta - Bioenergetics, >>
- Galkina Kseniia V., Zubareva Valeria M., Kashko Nataliia D., Lapashina Anna S., Markova Olga V., Feniouk Boris A., Knorre Dmitry A. (2022) Heterogeneity of starved yeast cells in IF1 levels suggests the role of this protein in vivo. Frontiers in microbiology, >>
- Lapashina Anna S., Feniouk Boris A. (2019) Mutation Q259L in subunit beta in Bacillus subtilis ATP synthase attenuates ADP-inhibition and decreases fitness in mixed cultures. Biochemical and Biophysical Research Communications, >>
- Lapashina AS, Prikhodko AS, Shugaeva TE, Feniouk BA (2019) Residue 249 in subunit beta regulates ADP inhibition and its phosphate modulation in Escherichia coli ATP synthase. Biochimica et Biophysica Acta - Bioenergetics, >>
- Lapashina A.S., Feniouk B.A. (2018) ADP-Inhibition of H+-FoF1-ATP synthase. Biochemistry (Moscow), >>