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The most cited biological Institute in Russia *

Vladimir P. Skulachev

Director, Academician of RAS, Grand PhD (Biology)
Contact
Telephone: 8 (495) 939-55-30
Address: корп. А, комн. 418
Fax: 8 (495) 939-03-38
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

Dean of the school of Bioengineering and Bioinformatics (MSU). Chief Editor of Biochemistry (Mosc.), the board member of FEBS Lett., Physiol. Rev., J. Bioenerg. Biomembr., Aging (Albany, N.Y.), Cell Cycle, etc.

Discoverer of “mitochondrial electricity” and “Skulachev Ions” (penetrating ions that are electrophoretically targeted to mitochondria) (1969). He proposed a theory of programmed aging as a mechanism increasing evolvability (1997). Skulachev also suggested that gradual programmed aging, seen in almost all mammals, has an evolutionary advantage over programmed sudden death seen in some animals such as salmon, octopus, and male marsupial mouse as well as many insects and plants.

Skulachev directs the SkQ Megaproject to study the effect of cationic plastoquinone derivatives (SkQs) inhibiting effects of ROS in mitochondria, interrupting the aging program, and consequently providing potential treatment agents for various age-related diseases. He also conducted a Homo Sapiens Liberatus Workshop in Moscow, May 2010 to review the SkQ results and discuss aging theories. Preliminary results are exciting, especially regarding age-related diseases of the eye, such as Dry eye syndrome. For this disease, clinical trial are already successfully completed.

Recent Papers
  1. Brzheskiy V.V., Efimova E.L., Vorontsova T.N., Alekseev V.N., Gusarevich O.G., Shaidurova K.N., Ryabtseva A.A., Andryukhina O.M., Kamenskikh T.G., Sumarokova E.S., Miljudin E.S., Egorov E.A., Lebedev O.I., Surov A.V., Korol A.R., Nasinnyk I.O., Bezditko P.A., Muzhychuk O.P., Vygodin V.A., Yani E.V., Savchenko A.Y., Karger E.M., Fedorkin O.N., Mironov A.N., Ostapenko V., Popeko N.A., Skulachev V.P., Skulachev M.V. (2015) Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome. Adv. Ther., 32 (12): 1263-1279. >>

  2. Shilovsky G.A., Putyatina T.S., Markov A.V., Skulachev V.P. (2015) Contribution of quantitative methods of estimating mortality dynamics to explaining mechanisms of aging. Biochem.-Moscow, 80 (12): 1547-1559. >>

  3. Isaev N.K., Stelmashook E.V., Genrikhs E.E., Oborina M.V., Kapkaeva M.R., Skulachev V.P. (2015) Alzheimer's disease: An exacerbation of senile phenoptosis. Biochem.-Moscow, 80 (12): 1578-1581. >>

  4. Khailova L.S., Nazarov P.A., Sumbatyan N.V., Korshunova G.A., Rokitskaya T.I., Dedukhova V.I., Antonenko Y.N., Skulachev V.P. (2015) Uncoupling and toxic action of alkyltriphenylphosphonium cations on mitochondria and the bacterium Bacillus subtilis as a function of alkyl chain length. Biochem.-Moscow, 80 (12): 1589-1597. >>

  5. Shilovsky G.A., Feniouk B.A., Skulachev V.P. (2015) Thymic involution in ontogenesis: Role in aging program. Biochem.-Moscow, 80 (12): 1629-1631. >>

  6. Silachev D.N., Plotnikov E.Y., Zorova L.D., Pevzner I.B., Sumbatyan N.V., Korshunova G.A., Gulyaev M.V., Pirogov Y.A., Skulachev V.P., Zorov D.B. (2015) Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury. Molecules, 20 (8): 14487-14503. >>

  7. Muntyan M.S., Cherepanov D.A., Malinen A.M., Bloch D.A., Sorokin D.Y., Severina I.I., Ivashina T.V., Lahti R., Muyzer G., Skulachev V.P. (2015) Cytochrome cbb(3) of Thioalkalivibrio is a Na+-pumping cytochrome oxidase. Proc. Natl. Acad. Sci. U. S. A., 112 (25): 7695-7700. >>

  8. Genrikhs E.E., Stelmashook E.V., Popova O.V., Kapay N.A., Korshunova G.A., Sumbatyan N.V., Skrebitsky V.G., Skulachev V.P., Isaev N.K. (2015) Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-beta-induced impairment of long-term potentiation in rat hippocampal slices. J. Drug Target., 23 (4): 347-352. >>

  9. Bertsova Y.V., Bogachev A.V., Skulachev V.P. (2015) Proteorhodopsin from Dokdonia sp PRO95 is a light-driven Na+-pump. Biochem.-Moscow, 80 (4): 449-454. >>

  10. Manskikh V.N., Gancharova S., Nikiforova I., Krasilshchikova S., Shabalina I.G., Egorov M.V., Karger E.M., Milanovsky G.E., Galkin I.I., Skulachev V.P., Zinovkin R.A. (2015) Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1. Histol. Histopath., 30 (3): 353-360. >>

  11. Weidinger A., Mullebner A., Paier-Pourani J., Banerjee A., Miller I., Lauterbock L., Duvigneau J.C., Skulachev V.P., Redl H., Kozlov A.V. (2015) Vicious Inducible Nitric Oxide Synthase-Mitochondrial Reactive Oxygen Species Cycle Accelerates Inflammatory Response and Causes Liver Injury in Rats. Antioxid. Redox Signal., 22 (7): 572-586. >>

  12. Iomdina E.N., Khoroshilova-Maslova I.P., Robustova O.V., Averina O.A., Kovaleva N.A., Aliev G., Reddy V.P., Zamyatnin A.A., Skulachev M.V., Senin I.I., Skulachev V.P. (2015) Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits. Front. Biosci., 20: 892-901. >>

  13. Fetisova E.K., Antoschina M.M., Cherepanynets V.D., Izumov D.S., Kireev I.I., Kireev R.I., Lyamzaev K.G., Riabchenko N.I., Chernyak B.V., Skulachev V.P. (2015) Radioprotective Effects of Mitochondria-Targeted Antioxidant SkQR1. Radiat. Res., 183 (1): 64-71. >>

  14. Shilov E.S., Kislyakov I.V., Gorshkova E.A., Zvartsev R.V., Drutskaya M.S., Mufazalov I.A., Skulachev V.P., Nedospasov S.A. (2014) Mouse Lymphomyeloid Cells Can Function with Significantly Decreased Expression Levels of Cytochrome c. Biochem.-Moscow, 79 (12): 1412-1422. >>

  15. Khailova L.S., Silachev D.N., Rokitskaya T.I., Avetisyan A.V., Lyamsaev K.G., Severina I.I., Il'yasova T.M., Gulyaev M.V., Dedukhova V.I., Trendeleva T.A., Plotnikov E.Y., Zvyagilskaya R.A., Chernyak B.V., Zorov D.B., Antonenko Y.N., Skulachev V.P. (2014) A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector. Biochim. Biophys. Acta-Bioenerg., 1837 (10): 1739-1747. >>

  16. Lokhmatikov A.V., Voskoboynikova N.E., Cherepanov D.A., Sumbatyan N.V., Korshunova G.A., Skulachev M.V., Steinhoff H.J., Skulachev V.P., Mulkidjanian A.Y. (2014) Prevention of peroxidation of cardiolipin liposomes by quinol-based antioxidants. Biochem.-Moscow, 79 (10): 1081-1100. >>

  17. Skulachev M.V., Severin F.F., Skulachev V.P. (2014) Receptor regulation of senile phenoptosis. Biochem.-Moscow, 79 (10): 994-1003. >>

  18. Skulachev M.V., Skulachev V.P. (2014) New data on programmed aging - slow phenoptosis. Biochem.-Moscow, 79 (10): 977-993. >>

  19. Vyssokikh M.Y., Chernyak B.V., Domnina L.V., Esipov D.S., Ivanova O.Y., Korshunova G.A., Symonyan R.A., Skulachev M.V., Zinevich T.V., Skulachev V.P. (2013) SkBQ - Prooxidant addressed to mitochondria. Biochem.-Moscow, 78 (12): 1366-1370. >>

  20. Dibrova D.V., Cherepanov D.A., Galperin M.Y., Skulachev V.P., Mulkidjanian A.Y. (2013) Evolution of cytochrome bc complexes: From membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates. Biochim. Biophys. Acta-Bioenerg., 1827 (11): 1407-1427. >>

  21. Pustovidko A.V., Rokitskaya T.I., Severina I.I., Simonyan R.A., Trendeleva T.A., Lyamzaev K.G., Antonenko Y.N., Rogov A.G., Zvyagilskaya R.A., Skulachev V.P., Chernyak B.V. (2013) Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria. Mitochondrion, 13 (5): 520-525. >>

  22. Trendeleva T.A., Sukhanova E.I., Rogov A.G., Zvyagilskaya R.A., Seveina I.I., Ilyasova T.M., Cherepanov D.A., Skulachev V.P. (2013) Role of charge screening and delocalization for lipophilic cation permeability of model and mitochondrial membranes. Mitochondrion, 13 (5): 500-506. >>

  23. Severin F.F., Feniouk B.A., Skulachev V.P. (2013) Advanced glycation of cellular proteins as a possible basic component of the "master biological clock". Biochem.-Moscow, 78 (9): 1043-1047. >>

  24. Plotnikov E.Y., Morosanova M.A., Pevzner I.B., Zorova L.D., Manskikh V.N., Pulkova N.V., Galkina S.I., Skulachev V.P., Zorov D.B. (2013) Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection. Proc. Natl. Acad. Sci. U. S. A., 110 (33): 0-0. >>

  25. Tsarev D.A., Zverev R.S., Kazmina E.M., Tashlitsky V.N., Skulachev V.P. (2013) Evaluating the Stability of a Cationic Plastoquinone Derivative (PDTP) in Visomitin Eye Drops. Pharm. Chem. J., 47 (4): 219-224. >>

  26. Severina I.I., Severin F.F., Korshunova G.A., Sumbatyan N.V., Ilyasova T.M., Simonyan R.A., Rogov A.G., Trendeleva T.A., Zvyagilskaya R.A., Dugina V.B., Domnina L.V., Fetisova E.K., Lyamzaev K.G., Vyssokikh M.Y., Chernyak B.V., Skulachev M.V., Skulachev V.P., Sadovnichii V.A. (2013) In search of novel highly active mitochondria-targeted antioxidants: Thymoquinone and its cationic derivatives. FEBS Lett., 587 (13): 2018-2024. >>

  27. Rokitskaya T.I., Ilyasova T.M., Severina I.I., Antonenko Y.N., Skulachev V.P. (2013) Electrogenic proton transport across lipid bilayer membranes mediated by cationic derivatives of rhodamine 19: comparison with anionic protonophores. Eur. Biophys. J. Biophys. Lett., 42 (6): 477-485. >>

  28. Kirpatovsky V.I., Plotnikov E.Y., Mudraya I.S., Golovanov S.A., Drozhzheva V.V., Khromov R.A., Chernikov D.Y., Skulachev V.P., Zorov D.B. (2013) Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention. Biochem.-Moscow, 78 (5): 542-548. >>

  29. Antonenko Y.N., Khailova L.S., Knorre D.A., Markova O.V., Rokitskaya T.I., Ilyasova T.M., Severina I.I., Kotova E.A., Karavaeva Y.E., Prikhodko A.S., Severin F.F., Skulachev V.P. (2013) Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria. PLoS One, 8 (4): . >>

  30. Kapay N.A., Popova O.V., Isaev N.K., Stelmashook E.V., Kondratenko R.V., Zorov D.B., Skrebitsky V.G., Skulachev V.P. (2013) Mitochondria-Targeted Plastoquinone Antioxidant SkQ1 Prevents Amyloid-beta-Induced Impairment of Long-Term Potentiation in Rat Hippocampal Slices. J. Alzheimers Dis., 36 (2): 377-383. >>

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