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Лаборатория биофизики мембран (биологически свободного окисления)
Research
Cooperation
Принадлежит к подразделению: Отдел биоэнергетики
Руководитель: доктор биологических наук, зав. лабораторией, профессор, Антоненко Юрий Николаевич

Page is under construction. Please visit laboratory of membrane biophysics on the old site.

Research areas: The laboratory studies mechanisms of Ion Transport across Membranes.

A scheme of a planar bilayer lipid membrane experiment. The scheme was designed by S.M.BezrukovA scheme of a planar bilayer lipid membrane experiment. The scheme was designed by S.M.Bezrukov



Обновлено 07.06.2012 15:39
Все статьи
  1. Serpionov G.V., Alexandrov A.I., Antonenko Y.N., Ter-Avanesyan M.D. (2015) A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast. Sci Rep, 5: . >>

  2. Khailova L.S., Nazarov P.A., Sumbatyan N.V., Korshunova G.A., Rokitskaya T.I., Dedukhova V.I., Antonenko Y.N., Skulachev V.P. (2015) Uncoupling and toxic action of alkyltriphenylphosphonium cations on mitochondria and the bacterium Bacillus subtilis as a function of alkyl chain length. Biochem.-Moscow, 80 (12): 1589-1597. >>

  3. Omarova E.O., Nazarov P.A., Firsov A.M., Strakhovskaya M.G., Arkhipova A.Y., Moisenovich M.M., Agapov I.I., Ol'shevskaya V.A., Zaitsev A.V., Kalinin V.N., Kotova E.A., Antonenko Y.N. (2015) Carboranyl-Chlorin e(6) as a Potent Antimicrobial Photosensitizer. PLoS One, 10 (11): . >>

  4. Silachev D.N., Zorova L.D., Usatikova E.A., Pevzner I.B., Babenko V.A., Gulyaev M.V., Pirogov Y.A., Antonenko Y.N., Plotnikov E.Y., Zorov D.B. (2015) Mitochondria As a Target for Neuroprotection. Biol. Membr., 32 (5): 388-398. >>

  5. Rokitskaya T.I., Firsov A.M., Kotova E.A., Antonenko Y.N. (2015) Photodynamic Inactivation of Gramicidin Channels in Bilayer Lipid Membranes: Protective Efficacy of Singlet Oxygen Quenchers Depends on Photosensitizer Location. Biochem.-Moscow, 80 (6): 745-751. >>

  6. Antonenko Y.N., Nechaeva N.L., Baksheeva V.E., Rokitskaya T.I., Plotnikov E.Y., Kotova E.A., Zorov D.B. (2015) Intramitochondrial accumulation of cationic Atto520-biotin proceeds via voltage-dependent slow permeation through lipid membrane. Biochim. Biophys. Acta-Biomembr., 1848 (6): 1277-1284. >>

  7. Antonenko Y.N., Rokitskaya T.I., Huczynski A. (2015) Electrogenic and nonelectrogenic ion fluxes across lipid and mitochondrial membranes mediated by monensin and monensin ethyl ester. Biochim. Biophys. Acta-Biomembr., 1848 (4): 995-1004. >>

  8. Firsov A.M., Kotova E.A., Korepanova E.A., Osipov A.N., Antonenko Y.N. (2015) Peroxidative permeabilization of liposomes induced by cytochrome c/cardiolipin complex. Biochim. Biophys. Acta-Biomembr., 1848 (3): 767-774. >>

  9. Silachev D.N., Khailova L.S., Babenko V.A., Gulyaev M.V., Kovalchuk S.I., Zorova L.D., Plotnikov E.Y., Antonenko Y.N., Zorov D.B. (2014) Neuroprotective effect of glutamate-substituted analog of gramicidin A is mediated by the uncoupling of mitochondria. Biochim. Biophys. Acta-Gen. Subj., 1840 (12): 3434-3442. >>

  10. Khailova L.S., Silachev D.N., Rokitskaya T.I., Avetisyan A.V., Lyamsaev K.G., Severina I.I., Il'yasova T.M., Gulyaev M.V., Dedukhova V.I., Trendeleva T.A., Plotnikov E.Y., Zvyagilskaya R.A., Chernyak B.V., Zorov D.B., Antonenko Y.N., Skulachev V.P. (2014) A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector. Biochim. Biophys. Acta-Bioenerg., 1837 (10): 1739-1747. >>

  11. Denisov S.S., Kotova E.A., Khailova L.S., Korshunova G.A., Antonenko Y.N. (2014) Tuning the hydrophobicity overcomes unfavorable deprotonation making octylamino-substituted 7-nitrobenz-2-oxa-1,3-diazole (n-octylamino-NBD) a protonophore and uncoupler of oxidative phosphorylation in mitochondria. Bioelectrochemistry, 98: 30-38. >>

  12. Rokitskaya T.I., Kotova E.A., Agapov I.I., Moisenovich M.M., Antonenko Y.N. (2014) Unsaturated lipids protect the integral membrane peptide gramicidin A from singlet oxygen. FEBS Lett., 588 (9): 1590-1595. >>

  13. Antonenko Y.N., Kotova E.A., Omarova E.O., Rokitskaya T.I., Ol'Shevskaya V.A., Kalinin V.N., Nikitina R.G., Osipchuk J.S., Kaplan M.A., Ramonova A.A., Moisenovich M.M., Agapov I.I., Kirpichnikov M.P. (2014) Photodynamic activity of the boronated chlorin e6 amide in artificial and cellular membranes. Biochim. Biophys. Acta-Biomembr., 1838 (3): 793-801. >>

  14. Omarova E.O., Antonenko Y.N. (2014) Inhibition of oxidative hemolysis in erythrocytes by mitochondria-targeted antioxidants of SkQ series. Biochem.-Moscow, 79 (2): 139-145. >>

  15. Shchepinova M.M., Denisov S.S., Kotova E.A., Khailova L.S., Knorre D.A., Korshunova G.A., Tashlitsky V.N., Severin F.F., Antonenko Y.N. (2014) Dodecyl and octyl esters of fluorescein as protonophores and uncouplers of oxidative phosphorylation in mitochondria at submicromolar concentrations. Biochim. Biophys. Acta-Bioenerg., 1837 (1): 149-158. >>

  16. Pustovidko A.V., Rokitskaya T.I., Severina I.I., Simonyan R.A., Trendeleva T.A., Lyamzaev K.G., Antonenko Y.N., Rogov A.G., Zvyagilskaya R.A., Skulachev V.P., Chernyak B.V. (2013) Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria. Mitochondrion, 13 (5): 520-525. >>

  17. Rokitskaya T.I., Ilyasova T.M., Severina I.I., Antonenko Y.N., Skulachev V.P. (2013) Electrogenic proton transport across lipid bilayer membranes mediated by cationic derivatives of rhodamine 19: comparison with anionic protonophores. Eur. Biophys. J. Biophys. Lett., 42 (6): 477-485. >>

  18. Antonenko Y.N., Khailova L.S., Knorre D.A., Markova O.V., Rokitskaya T.I., Ilyasova T.M., Severina I.I., Kotova E.A., Karavaeva Y.E., Prikhodko A.S., Severin F.F., Skulachev V.P. (2013) Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria. PLoS One, 8 (4): . >>

  19. Fedotcheva N.I., Mokhova E.N. (2013) Mechanism of induction of oxidative stress in liver mitochondria by low concentrations of tert-butyl hydroperoxide. Biochem.-Moscow, 78 (1): 75-79. >>

  20. Antonenko Y.N., Horner A., Pohl P. (2012) Electrostatically Induced Recruitment of Membrane Peptides into Clusters Requires Ligand Binding at Both Interfaces. PLoS One, 7 (12): . >>

  21. Rokitskaya T.I., Zaitsev A.V., Ol'shevskaya V.A., Kalinin V.N., Moisenovich M.M., Agapov I.I., Antonenko Y.N. (2012) Boronated derivatives of chlorin e(6) and fluoride-containing porphyrins as penetrating anions: a study using bilayer lipid membranes. Biochem.-Moscow, 77 (9): 975-982. >>

  22. Chernyak B.V., Antonenko Y.N., Galimov E.R., Domnina L.V., Dugina V.B., Zvyagilskaya R.A., Ivanova O.Y., Izyumov D.S., Lyamzaev K.G., Pustovidko A.V., Rokitskaya T.I., Rogov A.G., Severina I.I., Simonyan R.A., Skulachev M.V., Tashlitsky V.N., Titova E.V., Trendeleva T.A., Shagieva G.S. (2012) Novel mitochondria-targeted compounds composed of natural constituents: Conjugates of plant alkaloids berberine and palmatine with plastoquinone. Biochem.-Moscow, 77 (9): 983-995. >>

  23. Plotnikov E.Y., Silachev D.N., Jankauskas S.S., Rokitskaya T.I., Chupyrkina A.A., Pevzner I.B., Zorova L.D., Isaev N.K., Antonenko Y.N., Skulachev V.P., Zorov D.B. (2012) Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family. Biochem.-Moscow, 77 (9): 1029-1037. >>

  24. Il'yasova T.M., Rokitskaya T.I., Severina I.I., Antonenko Y.N., Skulachev V.P. (2012) Substitution of ether linkage for ester bond in phospholipids increases permeability of bilayer lipid membrane for SkQ1-type penetrating cations. Biochem.-Moscow, 77 (9): 1038-1043. >>

  25. Antonenko Y.N., Perevoshchikova I.V., Rokitskaya T.I., Simonyan R.A., Tashlitsky V.V., Skulachev V.P. (2012) Effect of liposomes on energy-dependent uptake of the antioxidant SkQR1 by isolated mitochondria. J. Bioenerg. Biomembr., 44 (4): 453-460. >>

  26. Sorochkina A.I., Plotnikov E.Y., Rokitskaya T.I., Kovalchuk S.I., Kotova E.A., Sychev S.V., Zorov D.B., Antonenko Y.N. (2012) N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler. PLoS One, 7 (7): . >>

  27. Rokitskaya T.I., Sorochkina A.I., Kovalchuk S.I., Egorova N.S., Kotova E.A., Sychev S.V., Antonenko Y.N. (2012) The pH-dependent induction of lipid membrane ionic permeability by N-terminally lysine-substituted analogs of gramicidin A. Eur. Biophys. J. Biophys. Lett., 41 (2): 129-138. >>

  28. Lyamzaev K.G., Pustovidko A.V., Simonyan R.A., Rokitskaya T.I., Domnina L.V., Ivanova O.Y., Severina I.I., Sumbatyan N.V., Korshunova G.A., Tashlitsky V.N., Roginsky V.A., Antonenko Y.N., Skulachev M.V., Chernyak B.V., Skulachev V.P. (2011) Novel Mitochondria-Targeted Antioxidants: Plastoquinone Conjugated with Cationic Plant Alkaloids Berberine and Palmatine. Pharmaceutical Research, 28 (11): 2883-2895.

  29. Kotova E.A., Kuzevanov A.V., Pashkovskaya A.A., Antonenko Y.N. (2011) Selective permeabilization of lipid membranes by photodynamic action via formation of hydrophobic defects or pre-pores. Biochimica et Biophysica Acta-Biomembranes, 1808 (9): 2252-2257.

  30. Springer A., Hagen V., Cherepanov D.A., Antonenko Y.N., Pohl P. (2011) Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface. Proceedings of the National Academy of Sciences of the United States of America, 108 (35): 14461-14466.

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