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The most cited biological Institute in Russia *

Лаборатория системной биологии старения

Лаборатория создана в 2017 году на средства гранта Правительства РФ («мегагранта»). Основное направление исследований – изучение возрастных изменений в живых организмах на молекулярном и клеточном уровне, с особым вниманием к механизмам поддержания протеастаза и регуляции биосинтеза белка. Возраст является одним из главных факторов риска таких болезней человека, как рак, диабет, болезни сердца и многие другие. Нарушения белкового синтеза вносят большой вклад в старение клеток и всего организма в целом. Методы системной биологии (например, рибосомный профайлинг) позволяют в одном эксперименте оценить количественные изменения экспрессии генов в клетках и тканях в масштабе всего генома. Лаборатория исследует прижизненные картины биосинтеза белков в разных органах молодых и пожилых животных в зависимости от различных факторов. Комбинация экспериментальных моделей и биоинформатики даёт возможность выявить молекулярные маркёры старения и найти клеточные мишени для борьбы с ним и сопутствующими ему заболеваниями.

Recent papers
  1. Klepikova A.V., Logacheva M.D., Dmitriev S.E., Penin A.A. (2015) RNA-seq analysis of an apical meristem time series reveals a critical point in Arabidopsis thaliana flower initiation. BMC Genomics, 16: . >>

  2. Dorokhov Y.L., Shindyapina A.V., Sheshukova E.V., Komarova T.V. (2015) METABOLIC METHANOL: MOLECULAR PATHWAYS AND PHYSIOLOGICAL ROLES. Physiol. Rev., 95 (2): 603-644. >>

  3. Andreev D.E., O'Connor P.B.F, Fahey C., Kenny E.M., Terenin I.M., Dmitriev S.E., Cormican P., Morris D.W., Shatsky I.N., Baranov P.V. (2015) Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. eLife, 4: . >>

  4. Putlyaeva L.V., Schwartz A.M., Korneev K.V., Covic M., Uroshlev L.A., Makeev V.Y., Dmitriev S.E., Kuprash D.V. (2014) Upstream Open Reading Frames Regulate Translation of the Long Isoform of SLAMF1 mRNA That Encodes Costimulatory Receptor CD150. Biochem.-Moscow, 79 (12): 1405-1411. >>

  5. Nikonorova I.A., Kornakov N.V., Dmitriev S.E., Vassilenko K.S., Ryazanov A.G. (2014) Identification of a Mg2+-sensitive ORF in the 5 '-leader of TRPM7 magnesium channel mRNA. Nucleic Acids Res., 42 (20): 12779-12788. >>

  6. Spirin P.V., Lebedev T.D., Orlova N.N., Gornostaeva A.S., Prokofjeva M.M., Nikitenko N.A., Dmitriev S.E., Buzdin A.A., Borisov N.M., Aliper A.M., Garazha A.V., Rubtsov P.M., Stocking C., Prassolov V.S. (2014) Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling. Leukemia, 28 (11): 2222-2228. >>

  7. Shindyapina A.V., Petrunia I.V., Komarova T.V., Sheshukova E.V., Kosorukov V.S., Kiryanov G.I., Dorokhov Y.L. (2014) Dietary Methanol Regulates Human Gene Activity. PLoS One, 9 (7): . >>

  8. Shatsky I.N., Dmitriev S.E., Andreev D.E., Terenin I.M. (2014) Transcriptome-wide studies uncover the diversity of modes of mRNA recruitment to eukaryotic ribosomes. Crit. Rev. Biochem. Mol. Biol., 49 (2): 164-177. >>

  9. Komarova T.V., Petrunia I.V., Shindyapina A.V., Silachev D.N., Sheshukova E.V., Kiryanov G.I., Dorokhov Y.L. (2014) Endogenous Methanol Regulates Mammalian Gene Activity. PLoS One, 9 (2): . >>

  10. Suntsova M., Gogvadze E.V., Salozhin S., Gaifullin N., Eroshkin F., Dmitriev S.E., Martynova N., Kulikov K., Malakhova G., Tukhbatova G., Bolshakov A.P., Ghilarov D., Garazha A., Aliper A., Cantor C.R., Solokhin Y., Roumiantsev S., Balaban P., Zhavoronkov A., Buzdin A. (2013) Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH. Proc. Natl. Acad. Sci. U. S. A., 110 (48): 19472-19477. >>

  11. Terenin I.M., Andreev D.E., Dmitriev S.E., Shatsky I.N. (2013) A novel mechanism of eukaryotic translation initiation that is neither m(7)G-cap-, nor IRES-dependent. Nucleic Acids Res., 41 (3): 1807-1816. >>

  12. Andreev D.E., Dmitriev S.E., Terenin I.M., Shatsky I.N. (2013) Cap-independent translation initiation of Apaf-1 mRNA based on a scanning mechanism is determined by some features of the secondary structure of its 5 ' untranslated region. Biochem.-Moscow, 78 (2): 157-165. >>

  13. Alexandrova E.A., Olovnikov I.A., Malakhova G.V., Zabolotneva A.A., Suntsova M.V., Dmitriev S.E., Buzdin A.A. (2012) Sense transcripts originated from an internal part of the human retrotransposon LINE-1 5 ' UTR. Gene, 511 (1): 46-53. >>

  14. Shagam L.I., Terenin I.M., Andreev D.E., Dunaevsky J.E., Dmitriev S.E. (2012) In vitro activity of human translation initiation factor eIF4B is not affected by phosphomimetic amino acid substitutions S422D and S422E. Biochimie, 94 (12): 2484-2490. >>

  15. Andreev D.E., Dmitriev S.E., Zinovkin R., Terenin I.M., Shatsky I.N. (2012) The 5 ' untranslated region of Apaf-1 mRNA directs translation under apoptosis conditions via a 5 ' end-dependent scanning mechanism. FEBS Lett., 586 (23): 4139-4143. >>

  16. Andreev D.E., Hirnet J., Terenin I.M., Dmitriev S.E., Niepmann M., Shatsky I.N. (2012) Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation. Nucleic Acids Res., 40 (12): 5602-5614. >>

  17. Dmitriev S.E., Stolboushkina E.A., Terenin I.M., Andreev D.E., Garber M.B., Shatsky I.N. (2011) Archaeal Translation Initiation Factor aIF2 Can Substitute for Eukaryotic eIF2 in Ribosomal Scanning during Mammalian 48S Complex Formation. Journal of Molecular Biology, 413 (1): 106-114.

  18. Vassilenko K.S., Alekhina O.M., Dmitriev S.E., Shatsky I.N., Spirin A.S. (2011) Unidirectional constant rate motion of the ribosomal scanning particle during eukaryotic translation initiation. Nucleic Acids Research, 39 (13): 5555-5567.

  19. Stepanov A.V., Belogurov A.A., Ponomarenko N.A., Stremovskiy O.A., Kozlov L.V., Bichucher A.M., Dmitriev S.E., Smirnov I.V., Shamborant O.G., Balabashin D.S., Sashchenko L.P., Tonevitsky A.G., Friboulet A., Gabibov A.G., Deyev S.M. (2011) Design of Targeted B Cell Killing Agents. Plos One, 6 (6): -.

  20. Shatsky I.N., Dmitriev S.E., Terenin I.M., Andreev D.E. (2010) Cap- and IRES-Independent Scanning Mechanism of Translation Initiation as an Alternative to the Concept of Cellular IRESs. Molecules and Cells, 30 (4): 285-293.

  21. Dmitriev S.E., Terenin I.M., Andreev D.E., Ivanov P.A., Dunaevsky J.E., Merrick W.C., Shatsky I.N. (2010) GTP-independent tRNA Delivery to the Ribosomal P-site by a Novel Eukaryotic Translation Factor. Journal of Biological Chemistry, 285 (35): 26779-26787.

  22. Andreev D.E., Dmitriev S.E., Terenin I.M., Prassolov V.S., Merrick W.C., Shatsky I.N. (2009) Differential contribution of the m(7)G-cap to the 5' end-dependent translation initiation of mammalian mRNAs. Nucleic Acids Research, 37 (18): 6135-6147.

  23. Dmitriev S.E., Andreev D.E., Adyanova Z.V., Terenin I.M., Shatsky I.N. (2009) Efficient cap-dependent translation of mammalian mRNAs with long and highly structured 5'-untranslated regions in vitro and in vivo. Molecular Biology, 43 (1): 108-113.

  24. Terenin I.M., Dmitriev S.E., Andreev D.E., Shatsky I.N. (2008) Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2. Nature Structural and Molecular Biology, 15 (8): 836-841.

  25. Andreev D.E., Fernandez-miragall O., Ramajo J., Dmitriev S.E., Terenin I.M., Martinez-salas E., Shatsky I.N. (2007) Differential factor requirement to assemble translation initiation complexes at the alternative start codons of foot- and-mouth disease virus RNA. RNA-Publ. RNA Soc., 13 (8): 1366-1374.

  26. Dmitriev S.E., Andreev D.E., Terenin I.M., Olovnikov I.A., Prassolov V.S., Merrick W.C., Shatsky I.N. (2007) Efficient translation initiation directed by the 900-nucleotide-long and GC-rich 5 ' untranslated region of the human retrotransposon LINE-1 mRNA is strictly cap dependent rather than internal ribosome entry site mediated. Molecular and Cellular Biology, 27 (13): 4685-4697.

  27. Olovnikov I.A., Adyanova Z.V., Galimov E.R., Andreev D.E., Terenin I.M., Ivanov D.S., Prassolov V.S., Dmitriev S.E. (2007) Key role of the internal 5'-UTR segment in the transcription activity of the human L1 retrotransposon. Molecular Biology, 41 (3): 453-458.

  28. Andreev D.E., Terenin I.M., Dmitriev S.E., Shatsky I.N. (2006) Similar features in mechanisms of translation initiation of mRNAS in eukaryotic and prokaryotic systems. Molecular Biology, 40 (4): 694-702.

  29. Andreev D.E., Terenin I.M., Dunaevsky Y.E., Dmitriev S.E., Shatsky I.N. (2006) A leaderless mRNA can bind to mammalian 80S ribosomes and direct polypeptide synthesis in the absence of translation initiation factors. Molecular and Cellular Biology, 26 (8): 3164-3169.

  30. Dmitriev S.E., Bykova N.V., Andreev D.E., Terenin I.M. (2006) Adequate system for investigation of the human retrotransposon L1 mRNA translation initiation in vitro. Molecular Biology, 40 (1): 25-30.

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