Site is under construction [Old site version]
The most cited biological Institute in Russia *

Fedor F. Severin

lab. head, Grand PhD (Biology)
Belongs to: Biological effects of membranophylic cations

Degrees conferred:

1987 - Moscow State University, Moscow, BSc, Biochemisry.

1992 - Moscow State University, Moscow, Ph.D. Molecular Biology.

2012 - Moscow State University, Moscow, Doctor of Science, Molecular Biology

University education:

1982-1987 Moscow State University, Moscow. Biochemistry.

Research Experience:

1.86-1.87 - Research Assistant: Institute of Protein Research RAS. (laboratory of Prof. A.S. Spirin) Study on phosphorylation of elongation factor 2

1.87-12.88 - Professional training, Institute of Protein Research RAS. (laboratory of Dr. V.I Gelfand) The establishment of in vitro assay for kinesin- induced microtubule movement.

1.89-12.92 - Graduate student: Institute of Protein Research RAS. (laboratory of Dr. V.I Gelfand) Study on interaction of microtubules with vesicles and with each other.

1.93-3.93 - Research associate. (laboratory of Dr V.I Gelfand) Study on interaction of microtubules with each other.

4.93-5.99 - Postdoctoral research. European Molecular Biology Laboratory, (lab. of Dr. Anthony A. Hyman). Study on S. cerevisiae kinetochore and mitotic spindle

6.99-1.2002 - Postdoctoral research. Max Planck Institute of Molecular Cell Biology and Genetics. (lab. of Dr. Anthony A. Hyman). Study on S. cerevisiae kinetochore and mitotic spindle

1.02-12.2003 - Postdoctoral research. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden (lab.of Dr. Marino Zerial). Study on microtubule-based endosome motility

1.04 – 3.2006 - Staff scientist. Biotech Zentrum, TU Dresden. Lab. of Dr. Daniel Mueller. Study of microtubule and actin filament structures using atomic force microscopy.

04.2006 - Groupleader. A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119992

No military service, no non-scientific activities.

Recent Papers
  1. Kalebina T.S., Sokolov S.S., Selyakh I.O., Vanichkina D.P., Severin F.F. (2015) Amiodarone induces cell wall channel formation in yeast Hansenula polymorpha. SpringerPlus, 4: . >>

  2. Karavaeva I.E., Shekhireva K.V., Severin F.F., Knorre D.A. (2015) Does mitochondrial fusion require transmembrane potential?. Biochem.-Moscow, 80 (5): 549-558. >>

  3. Sokolov S.S., Balakireva A.V., Markova O.V., Severin F.F. (2015) Negative feedback of glycolysis and oxidative phosphorylation: Mechanisms of and reasons for it. Biochem.-Moscow, 80 (5): 559-564. >>

  4. Skulachev M.V., Severin F.F., Skulachev V.P. (2014) Receptor regulation of senile phenoptosis. Biochem.-Moscow, 79 (10): 994-1003. >>

  5. Knorre D.A., Markova O.V., Smirnova E.A., Karavaeva I.E., Sokolov S.S., Severin F.F. (2014) Dodecyltriphenylphosphonium inhibits multiple drug resistance in the yeast Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 450 (4): 1481-1484. >>

  6. Shchepinova M.M., Denisov S.S., Kotova E.A., Khailova L.S., Knorre D.A., Korshunova G.A., Tashlitsky V.N., Severin F.F., Antonenko Y.N. (2014) Dodecyl and octyl esters of fluorescein as protonophores and uncouplers of oxidative phosphorylation in mitochondria at submicromolar concentrations. Biochim. Biophys. Acta-Bioenerg., 1837 (1): 149-158. >>

  7. Severin F.F., Feniouk B.A., Skulachev V.P. (2013) Advanced glycation of cellular proteins as a possible basic component of the "master biological clock". Biochem.-Moscow, 78 (9): 1043-1047. >>

  8. Pyrkov T.V., Sevostyanova I.A., Schmalhausen E.V., Shkoporov A.N., Vinnik A.A., Muronetz V.I., Severin F.F., Fedichev P.O. (2013) Structure-Based Design of Small-Molecule Ligands of Phosphofructokinase-2 Activating or Inhibiting Glycolysis. ChemMedChem, 8 (8): 1322-1329. >>

  9. Dumina M.V., Zhgun A.A., Kerpichnikov I.V., Domracheva A.G., Novak M.I., Valiachmetov A.Y., Knorre D.A., Severin F.F., Eldarov M.A., Bartoshevich Y.E. (2013) Functional analysis of MFS protein CefT involved in the transport of beta-lactam antibiotics in Acremonium chrysogenum and Saccharomyces cerevisiae. Appl. Biochem. Microbiol., 49 (4): 368-377. >>

  10. Severina I.I., Severin F.F., Korshunova G.A., Sumbatyan N.V., Ilyasova T.M., Simonyan R.A., Rogov A.G., Trendeleva T.A., Zvyagilskaya R.A., Dugina V.B., Domnina L.V., Fetisova E.K., Lyamzaev K.G., Vyssokikh M.Y., Chernyak B.V., Skulachev M.V., Skulachev V.P., Sadovnichii V.A. (2013) In search of novel highly active mitochondria-targeted antioxidants: Thymoquinone and its cationic derivatives. FEBS Lett., 587 (13): 2018-2024. >>

  11. Starovoytova A.N., Sorokin M.I., Sokolov S.S., Severin F.F., Knorre D.A. (2013) Mitochondrial signaling in Saccharomyces cerevisiae pseudohyphae formation induced by butanol. FEMS Yeast Res., 13 (4): 367-374. >>

  12. Antonenko Y.N., Khailova L.S., Knorre D.A., Markova O.V., Rokitskaya T.I., Ilyasova T.M., Severina I.I., Kotova E.A., Karavaeva Y.E., Prikhodko A.S., Severin F.F., Skulachev V.P. (2013) Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria. PLoS One, 8 (4): . >>

  13. Litvinchuk A.V., Sokolov S.S., Rogov A.G., Markova O.V., Knorre D.A., Severin F.F. (2013) Mitochondrially-encoded protein Var1 promotes loss of respiratory function in Saccharomyces cerevisiae under stressful conditions. Eur. J. Cell Biol., 92 (4): 169-174. >>

  14. Knorre D.A., Popadin K.Y., Sokolov S.S., Severin F.F. (2013) Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells. Oxidative Med. Cell. Longev., 2013: . >>

  15. Gavrilova N.S., Gavrilov L.A., Severin F.F., Skulachev V.P. (2012) Testing predictions of the programmed and stochastic theories of aging: Comparison of variation in age at death, menopause, and sexual maturation. Biochem.-Moscow, 77 (7): 754-760. >>

  16. Sukhanova E.I., Rogov A.G., Severin F.F., Zvyagilskaya R.A. (2012) Phenoptosis in yeasts. Biochem.-Moscow, 77 (7): 761-775. >>

  17. Knorre D.A., Severin F.F. (2012) Longevity and mitochondrial membrane potential. Biochem.-Moscow, 77 (7): 793-794. >>

  18. Skulachev M.V., Antonenko Y.N., Anisimov V.N., Chernyak B.V., Cherepanov D.A., Chistyakov V.A., Egorov M.V., Kolosova N.G., Korshunova G.A., Lyamzaev K.G., Plotnikov E.Y., Roginsky V.A., Savchenko A.Y., Severina I.I., Severin F.F., Shkurat T.P., Tashlitsky V.N., Shidlovsky K.M., Vyssokikh M.Y., Zamyatnin A.A., Zorov D.B., Skulachev V.P. (2011) Mitochondrial-Targeted Plastoquinone Derivatives. Effect on Senescence and Acute Age-Related Pathologies. Current Drug Targets, 12 (6): 800-826.

  19. Antonenko Y.N., Avetisyan A.V., Cherepanov D.A., Knorre D.A., Korshunova G.A., Markova O.V., Ojovan S.M., Perevoshchikova I.V., Pustovidko A.V., Rokitskaya T.I., Severina I.I., Simonyan R.A., Smirnova E.A., Sobko A.A., Sumbatyan N.V., Severin F.F., Skulachev V.P. (2011) Derivatives of Rhodamine 19 as Mild Mitochondria-targeted Cationic Uncouplers. Journal of Biological Chemistry, 286 (20): 17831-17840.

  20. Knorre D.A., Smirnova E.A., Markova O.V., Sorokin M.I., Severin F.F. (2011) Prooxidants prevent yeast cell death induced by genotoxic stress. Cell Biology International, 35 (5): 431-435.

  21. Ojovan S.M., Knorre D.A., Markova O.V., Smirnova E.A., Bakeeva L.E., Severin F.F. (2011) Accumulation of dodecyltriphenylphosphonium in mitochondria induces their swelling and ROS-dependent growth inhibition in yeast. Journal of Bioenergetics and Biomembranes, 43 (2): 175-180.

  22. Kochmak S.A., Knorre D.A., Sokolov S.S., Severin F.F. (2011) Physiological Scenarios of Programmed Loss of Mitochondrial DNA Function and Death of Yeast. Biochemistry-Moscow, 76 (2): 167-171.

  23. Knorre D.A., Kulemzina I.A., Sorokin M.I., Kochmak S.A., Bocharova N.A., Sokolov S.S., Severin F.F. (2010) Sir2-dependent daughter-to-mother transport of the damaged proteins in yeast is required to prevent high stress sensitivity of the daughters. Cell Cycle, 9 (22): 4501-4505.

  24. Skulachev V.P., Antonenko Y.N., Cherepanov D.A., Chernyak B.V., Izyumov D.S., Khailova L.S., Klishin S.S., Korshunova G.A., Lyamzaev K.G., Pletjushkina O.Y., Roginsky V.A., Rokitskaya T.I., Severin F.F., Severina I.I., Simonyan R.A., Skulachev M.V., Sumbatyan N.V., Sukhanova E.I., Tashlitsky V.N., Trendeleva T.A., Vyssokikh M.Y., Zvyagilskaya R.A. (2010) Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs). Biochimica et Biophysica Acta-Bioenergetics, 1797 (6): 878-889.

  25. Severin F.F., Severina I.I., Antonenko Y.N., Rokitskaya T.I., Cherepanov D.A., Mokhova E.N., Vyssokikh M.Y., Pustovidko A.V., Markova O.V., Yaguzhinsky L.S., Korshunova G.A., Sumbatyan N.V., Skulachev M.V., Skulachev V.P. (2010) Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore. Proceedings of the National Academy of Sciences of the United States of America, 107 (2): 663-668.

  26. Knorre D.A., Krivonosova T.N., Markova O.V., Severin F.F. (2009) Amiodarone inhibits multiple drug resistance in yeast Saccharomyces cerevisiae. Archives of Microbiology, 191 (8): 675-679.

  27. Bocharova N., Chave-cox R., Sokolov S., Knorre D., Severin F. (2009) Protein aggregation and neurodegeneration: Clues from a yeast model of Huntington's disease. Biochemistry-Moscow, 74 (2): 231-234.

  28. Bocharova N.A., Sokolov S.S., Knorre D.A., Skulachev V.P., Severin F.F. (2008) Unexpected link between anaphase promoting complex and the toxicity of expanded polyglutamines expressed in yeast. Cell Cycle, 7 (24): 3943-3946.

  29. Knorre D., Ojovan S., Saprunova V., Sokolov S., Bakeeva L., Severin F. (2008) Mitochondrial matrix fragmentation as a protection mechanism of yeast Saccharomyces cerevisiae. Biochemistry-Moscow, 73 (11): 1254-1259.

  30. Severin F.F., Meer M.V., Smirnova E.A., Knorre D.A., Skulachev V.P. (2008) Natural causes of programmed death of yeast Saccharomyces cerevisiae. Biochimica et Biophysica Acta-Molecular Cell Research, 1783 (7): 1350-1353.

More articles