Publications:
1. Regulation of cytokine
gene transcription:
1. Baer M, Dillner
A, Schwartz RC, Sedon C, Nedospasov
SA, Johnston PF. TNF alpha transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-kB p50. Mol.Cell.Biol. 1998; 18:5678-5689.
2.
Kaijzel EL, van Krugten MV, Brinkman BM, et al. Functional analysis of a human
tumor necrosis factor alpha (TNF-alpha) promoter polymorphism related to joint
damage in rheumatoid arthritis. Mol Med 1998; 4:724-733.
3. Udalova IA, Knight JC, Vidal V, Nedospasov SA, Kwiatkowski D. Complex NF-kappaB interactions at the distal tumor necrosis factor
promoter region in human monocytes. J.Biol.Chem.
1998; 273: 21178-21186.
4. Kuprash DV, Udalova
IA, Turetskaya RL, Kwiatkowski D, Rice NR, Nedospasov SA. Similarities and
differences between human and murine TNF promoters in
their response to lipopolysaccharide. J Immunol 1999; 162: 4045-4052.
5. Kuprash DV, Boitchenko
VE, Yarovinsky FO, Rice NR, Nordheim
A, Ruhlmann A, Nedospasov
SA. Cyclosporin A blocks the expression of lymphotoxin alpha, but not lymphotoxin
beta, in human peripheral blood mononuclear cells. Blood.
2002; 100(5): 1721-1727.
2. Physiological functions
of cytokines:
6. Endres R,
7. Ito D, Back TC, Shakhov AN, Wiltrout RH, Nedospasov SA. Mice
with a Targeted Mutation in Lymphotoxin-alpha Exhibit
Enhanced Tumor Growth and Metastasis: Impaired NK Cell Development and
Recruitment. J Immunol 1999; 163: 2809-2815.
8. Kuprash DV, Alimzhanov
MB, Tumanov A, Anderson AO, Pfeffer
K, Nedospasov SA. TNF and Lymphotoxin
beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph
nodes. J Immunol 1999; 163: 6575-6580.
9. Drize NI, Drutskaya
MS, Gerasimova LP, Manakova
TE, Chertkov IL, Turetskaya
RL, Kuprash DV, Nedospasov
SA. Changes in the hemopoietic system of mice
deficient for tumor necrosis factor or lymphotoxin-alpha.
Bull Exp
Biol Med [Russian] 2000; 130 (7): 76-79.
10.
Shakhov AN, Lyakhov IG, Tumanov AV, et al. Gene profiling approach in the
analysis of lymphotoxin and TNF deficiencies. J Leukoc Biol 2000; 68: 151-157.
11. Shakhov AN, Rubtsov
AV, Lyakhov IG, Tumanov A, Nedospasov SA. SPLASH (PLA211D), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency. Genes Immunity 2000; 1: 191-199.
12. Drutskaya MS, Kuprash DV, Nedospasov SA,
13.
Shakhov AN, Nedospasov SA. Expression profiling in knockout mice: lymphotoxin versus tumor necrosis factor in the maintenance
of splenic microarchitecture.
Cytokine Growth Factor Rev 2001; 12: 107-119.
14. Hehlgans T, Stoelcker
B, Stopfer P, Muller P, Cernaianu
G, Guba M, Steinbauer M, Nedospasov SA, Pfeffer K, Mannel DN. Lymphotoxin-beta
receptor immune interaction promotes tumor growth by inducing angiogenesis.
Cancer Res. 2002 62: 4034-40
15. Kuprash D.V. Alimzhanov M.B., Tumanov A.V.,
Ito D., Abe, K., Turetskaya, R.L., Marino, M.W.,
Anderson A.O., Rajewsky K., Pfeffer
K. and Nedospasov S.A. Mutiple
deficiencies in immune functions in mice with complete neo-free deletion of the
TNF/LT locus (TNF/LTbeta/LTalpha triple-deficient
mice). Mol. Cell. Biol., 2002, 22:8626-8634.
16. Tumanov, A.V., Kuprash, D.V., Lagarkova, M.A., Grivennikov, S.I., Abe, K., Shakhov,
A.N., Drutskaya. L.N., Stewart C.L., Chervonsky, A.V. and
17. Abe, K., Yarovinsky, F.,
Murakami, T., Ito, D., Tumanov, A.V., Pfeffer, K., Shakhov, A.N., Kuprash, D.V., Komschlies, K.L.,
and Nedospasov, S.A. Distinct role of TNF/LT
subfamily of cytokines in the development and recruitment of dendritic cells. Blood, 2003, 101:1477-1483.
18. Grivennikov SI, Tumanov AV, Liepinsh DJ, Kruglov AA, Marakusha BI, Shakhov AN, Murakami T, Drutskaya
LN, Forster I, Clausen BE, Tessarollo L, Ryffel B, Kuprash DV, Nedospasov SA. Distinct and non-redundant in vivo functions
of TNF produced by T cells and macrophages/neutrophils:
protective and deleterious effects. Immunity 2005, 22: 93-104.
19. Liepinsh DJ, Grivennikov SI, Klarmann KD, Lagarkova MA, Drutskaya MS,
Lockett SJ, Tessarollo L, McAuliffe M, Keller JR, Kuprash DV, Nedospasov SA. Novel lymphotoxin alpha (LTalpha)
knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions. Mol Cell Biol
2006, 26:4214-4225.
20. Cui CY, Kunisada M, Esibizione D, Grivennikov SI, Piao Y, Nedospasov SA, Schlessinger D.
Lymphotoxin-{beta}
regulates periderm differentiation during embryonic
skin development.
Hum Mol Genet. 2007 Aug 1; [Epub ahead of print]
21. Togbe D, Grivennikov SI, Noulin N, Couillin I, Maillet I, Jacobs M, Maret M, Fick L, Nedospasov SA, Quesniaux VF, Schnyder B, Schnyder-Candrian S. T cell-derived TNF down-regulates acute airway response to endotoxin. Eur J Immunol. 2007;37(3):768-79.
3. Human cancer antigens
and serology:
22. Lagarkova
MA, Boitchenko VE, Mescheryakov
AA, Kashkarova UA, Nedospasov
SA. Human cortactin as putative cancer antigen. Oncogene 2000; 19: 5204-5207.
23. Kuimov AN, Kuprash
DV, Petrov VN, Vdovichenko
KK, Scanlan MJ, Jongeneel
CV, Lagarkova MA, Nedospasov
SA. Cloning and characterization of TNKL, a member of tankyrase
gene family. Genes Immun 2001; 2: 52-55.
24. Koroleva EP, Lagarkova MA, Mesheryakov AA, Scanlan MJ, Old LJ, Nedospasov
SA, Kuprash DV. Serological identification of
antigens assosiated with renal cell carcinoma.
Russian Journal of Immunology, 2002, 7(3):229-238.
25. Lagarkova MA, Koroleva EP, Kuprash DV, Boitchenko VE, Kashkarova UA, Nedospasov SA, Shebzukhov YV.
Evaluation of humoral response to tumor antigens
using recombinant expression-based serological mini-arrays (SMARTA). Immunology
Letters, 2003, 85(1):71-74.
26. Koroleva EP, Lagarkova MA, Khlgatian SV, Shebzukhov YV, Mescheryakov AA, Lichinitser MR, Nedospasov SA, Kuprash DV. Serologic analysis of repertoire of human
cancer antigens and autoantigens. Mol. biologiya [Russian], 2004, 38: 1-6.
27. Shebzukhov YV, Koroleva EP, Khlgatian SV, Belousov PV, Kuz’mina KE, Radko BV, Longpre F, Lagarkova MA, Kadachigova TS, Gurova OV, Mescheryakov AA, Lichinitser MR, Knuth A, Jager E,
Kuprash DV, and Nedospasov
SA. Humoral immune response to a non-conserved
C-terminal part of human histone deacetylase
3 in colon cancer patients. Int. J. Cancer 2005a; 117(5):800-806.
28. Shebzukhov YV, Koroleva EP, Khlgatian SV, Lagarkova MA, Meshcheryakov AA, Lichinitser MR, Karbach J, Jager E, Kuprash DV, Nedospasov SA. Humoral
immune response to thymidylate synthase
in colon cancer patients after 5-FU chemotherapy. Immunol
Lett. 2005b; 100(1): 88-93.
29. Shebzukhov YV, Koroleva EP, Khlgatian SV, Belousov PV, Sazykin AY, Kadachigova TS, Pomerantseva EA, Lagarkova MA, Nedospasov SA, Kuprash DV. RAP80/UIMC1 as
cancer-associated antigen: alternative splice variants and their immunogenicity. Cancer Lett. 2007; 255(2):255-62.
Epub 2007 Jun 11.
4. Other research in
molecular immunology and hematology:
30. Schroeder HW Jr,
Zhu ZB, March RE, Campbell RD, Berney SM, Nedospasov SA, Turetskaya RL,
Atkinson TP, Go RC, Cooper MD, Volanakis JE.
Susceptibility locus for IgA deficiency and common
variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes.
Mol Med. 1998, 4:72-86.
31. Korobko VG, Boichenko
VE, Kuprash DV, Turetskaia
RL, Nedospasov SA. [Heterologous
expression of murine lymphotoxins
in Escherichia coli and preparation of antibodies]. Bioorg
Khim. 1999 Apr; 25(4):270-274.
32. Boitchenko
VE, Korobko VG, Prasolov
VS, Kravchenko VV, Kuimov
AN, Turetskaya RL, Kuprash
DV, Nedospasov SA. Immunodetection
of murine lymphotoxins in
eukaryotic cells. Russian J Immunol 2000; 5:259-266.
33. Eskdale J, Turetskaya
RL, Armstrong C, Kuprash DV, Nedospasov
SA, Gallagher G. A polymorphic microsatellite marker
in the human p55 TNF receptor, CD120a. Genes Immun
2000; 1: 228-230.
34. Boitchenko VE, Alimzhanov MB, Turetskaya RL, Ruhlmann A, Nordheim A, Kuprash DV, Nedospasov SA.
[Comparative Characterization of Lymphotoxin
Transcripts from Human B- and T-Cell Lines, Peripheral Lymphocytes, and
35. Radko BV, Boitchenko
VE, Nedospasov SA, Korobko
VG. Characterization of the genes encoding variable light and heavy chains of
the high-affinity monoclonal antibody against human tumor necrosis factor.
Russian Journal of Immunology, 2002, 7(4): 371-374.
5. Other
research in molecular biology:
36. Kashkin KN, Khlgatian SV, Gurova OV, Kuprash DV, Nedospasov SA. New mutations in the human p53 gene – a regulator of the cell
cycle and carcinogenesis. Biochemistry (Mosc). 2007, 72(3):282-92
6. Reviews:
37. Nedospasov
SA, Grivennikov SI, Kuprash
DV. Physiologic roles of members of the TNF and TNF receptor
families as revealed by knockout models. In: "Contemporary
immunology: Cytokine Knockouts" 2nd edition, Giamila
Fantuzzi, Ed., 2003, Humana Press, Inc.,
38. Nedospasov SA, Kuprash DV. [Cytokines, their receptors
and intracellular signal transduction]. In: Cancerogenesis
[Russian], DG Zaridze ed., 2004, Meditsina,
39. Nedospasov SA, Lavrik IN. [Mechanisms of activation of programmed cell
death via death receptors]. In: Cancerogenesis
[Russian], DG Zaridze ed., 2004, Meditsina,
40. Nedospasov
SA, Kuprash DV. Oncoimmunology:
some fundamental problems of cancer immunotherapy. Mol Biol (Mosk). 2007 Mar-Apr;
41(2): 355-68.
41. Shebzukhov IuV, Belousov PV,
Khlgatian SV, Sazykin AIu, Kuprash DV, Nedospasov SA. Contemporary
molecular-biological methods of cancer diagnosis and monitoring based on the humoral immune response to tumor-associated antigens. Mol Gen Mikrobiol Virusol.
2007;(2):3-6.
42. Belousov PV, Shezbukhov IuV, Nedospasov SA, Kuprash DV.Onconeural antibodies as a tool for diagnosis of malignant tumors and paraneoplastic neurological disorders. Mol Gen
Mikrobiol Virusol. 2007;(2):6-13.
Last
update October 17, 2007 by Dmitry Kuprash and Maria Goncharskaya